The film documents, in an often dramatic and humorous fashion, Gray's investigations into alternative medicine for an eye condition (Macular pucker) he had developed.
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| Directing | Steven Soderbergh | Director |
| Writing | Spalding Gray | Writer |
| Writing | Renée Shafransky | Writer |
| Editing | Susan Littenberg | Editor |
| Sound | Cliff Martinez | Original Music Composer |
| Production | John Hardy | Producer |
| Production | Caroline Kaplan | Executive Producer |
| Production | Kathleen Russo | Executive Producer |
| Production | Jonathan Sehring | Executive Producer |
| Art | Cynthia Wigginton | Set Decoration |
| Costume & Make-Up | Charley Soderbergh | Makeup & Hair |
| Crew | Huey Mitchell | Carpenter |
| Art | John Patterson | Construction Coordinator |
| Crew | Larry Spurlock | Carpenter |
| Sound | Paul Ledford | Production Sound Mixer |
| Sound | Mark Mangini | Sound Editor |
| Sound | Keenan Wyatt | Boom Operator |
| Crew | Mike Malone | Special Effects |
| Production | David Jensen | Casting |
| Camera | Tony Brignac | First Assistant Camera |
| Camera | Buddy Carr | Second Assistant Camera |
| Camera | Gilly Charbonnet | Grip |
| Lighting | Calvin Maehl | Chief Lighting Technician |
| Camera | Richard Mall | Key Grip |
| Lighting | Chris Robertson | Electrician |
| Camera | Val Zimmer | Grip |
| Crew | Howard Behar | Legal Services |
| Production | Billy Collins Jr. | Production Accountant |
| Production | Lori Jefferson | Production Assistant |
| Crew | Debbie Kennedy | Legal Services |
| Production | Tara Martin | Production Coordinator |
| Production | Tom Mustafo | Production Assistant |
| Crew | Adam Rosen | Legal Services |
| Sound | Larry Blake | Sound Re-Recording Mixer |
| Camera | Elliot Davis | Director of Photography |
| Art | Adele Plauche | Production Design |
| Art | Mike Malone | Props |
| Lighting | David Jensen | Electrician |
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