Pierre Vignol, an artist wintering in Arizona, is bitten by a snake. He is taken by his friend, Tom Hornby, to Padre Francisco, who prescribes for the bite. Pierre, at the request of Tom, returns to his cabin and Tom takes care of him. Later Tom discovers a tube in Lost River. This proves to be a painting and Pierre takes it to Padre Francisco. The Padre reads him an interesting history of Fr. Bartolomeo. founder of the Mission, and of how the painting came to be discovered in Lost River, for it had been thrown there by a monk when the Mission was attacked by the Indians, owing to the abduction of the Chief's daughter by a villainous Spaniard. Tom takes the painting to New York where he sells it and gives the money to the wife of Tom, who has been too poor to bring her and the baby to Arizona.

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